Nuclear Factor-κB1 (p50) Limits the Inflammatory and Fibrogenic Responses to Chronic Injury
نویسندگان
چکیده
منابع مشابه
p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance.
Tumor-associated macrophages (TAM) are a major inflammatory infiltrate in tumors and a major component of the protumor function of inflammation. TAM in established tumors generally have an M2 phenotype with defective production of interleukin-12 (IL-12) and high IL-10. Here, we report that defective responsiveness of TAM from a murine fibrosarcoma and human ovarian carcinoma to M1 activation si...
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The polypeptide (p)50 molecule, a subunit of nuclear factor (NF)-kappaB, is produced after proteolytic processing of the p105 precursor (NF-kappaB1). Although the p105 precursor has been postulated to play a role in the regulation of the Rel/NF-kappaB activity, its physiological relevance remains unclear. To investigate that, we generated mutant mice lacking the COOH terminal half of the p105 p...
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nf-κb pathway is a link between inflammation and cancer and is involved in cellular responses to different stimuli. gastrointestinal lumen is exposed to many inflammatory agents such as foods, free radicals and bacterial or viral antigens. the aim of the present study was to evaluate the possible role of nf-κb1in gastric adenocarcinoma. to detect the relative level of nf-κb1transcript, total rn...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2005
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)62291-2